Sleep Aging and Risk for Alzheimer's Resubmission 2.0
Official Summary
Age-related sleep changes and common sleep disorders like obstructive sleep apnea (OSA) may increase amyloid burden and represent risk factors for cognitive decline in the elderly. We will directly interrogate the brain using a 2-night nocturnal polysomnography (NPSG) and amyloid deposition using C-PiB PET/MR both at baseline and at the 24-month follow-up. This study has the potential to identify the mechanisms by which age-related sleep changes contribute to AD neurodegeneration in cognitively normal elderly, the group that could profit the most from sleep preventive strategies.
Study Design
- Study Type: OBSERVATIONAL
- Enrollment: 158 participants
Interventions
- DIAGNOSTIC_TEST: PET Scan and nocturnal polysomnography — Amyloid PET scans will be used to assess amyloid burden in the brain, and nocturnal polysomnography will be used to assess sleep and cardiopulmonary variables
Primary Outcomes
- Establishing how mild-to-moderate OSA increases AD risk will inform novel preventive therapies for AD. (2.5 years)
Secondary Outcomes
- Establishing that SWS quality is associated with longitudinal amyloid deposition will identify a key mechanism by which age increases AD risk. (2.5 years)
Trial Locations
- Healthy Brain Aging and Sleep Center, New York, New York, United States
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AI-generated analysis for educational purposes only. This is not medical advice. Discuss clinical trial participation with your doctor. Data sourced from ClinicalTrials.gov.