The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect
NCT: NCT06058585 ·
Status: RECRUITING ·
Phase: Phase 3
· Sponsor: The George Institute
· Started: 2024-09-04
· Est. Completion: 2029-03-31
Official Summary
CAPTIVATE is an international, multi-centre, Phase III, adaptive, platform, randomised controlled trial in people with chronic kidney disease (CKD). CAPTIVATE aims to find the best treatment, or combination of treatments, that slow the progression of CKD so that fewer people develop kidney failure. CAPTIVATE provides a research platform that allows many treatment-related questions to be answered within a common trial set-up.
Study Design
- Study Type: INTERVENTIONAL
- Allocation: RANDOMIZED
- Model: FACTORIAL
- Masking: QUADRUPLE
- Enrollment: 1,000 participants
Interventions
- DRUG: Finerenone — Finerenone 10mg or 20mg tablets, oral, once daily
- DRUG: Placebo Finerenone — Finerenone matched placebo tablets, oral, once daily
Primary Outcomes
- eGFR slope (From randomisation to week 108)
Secondary Outcomes
- Change in albuminuria (From randomisation to week 24)
- Composite of 40% eGFR decline or kidney failure (From randomisation to week 108)
- All-cause mortality at 108 weeks (108 weeks)
- Number of cardiovascular events (108 weeks)
- Safety and tolerability of treatment (108 weeks)
Trial Locations
- The Canberra Hospital, Garran, Australian Capital Territory, Australia
- Nepean Blue Mountains Local Health District, Kingswood, New South Wales, Australia
- St George Hospital, Kogarah, New South Wales, Australia
- John Hunter Hospital, New Lambton Heights, New South Wales, Australia
- Westmead Hospital, Westmead, New South Wales, Australia
- Sunshine Coast Hospital and Health Service, Birtinya, Queensland, Australia
- Townsville University Hospital, Douglas, Queensland, Australia
- West Moreton Hospital & Health Service, Ipswich, Queensland, Australia
- Gold Coast Hospital and Health Service, Southport, Queensland, Australia
- Royal Adelaide, Adelaide, South Australia, Australia
- ...and 10 more locations
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AI-generated analysis for educational purposes only. This is not medical advice. Discuss clinical trial participation with your doctor. Data sourced from ClinicalTrials.gov.