Effect of Intraoperative Fluid Management Guided by Respiratory Variations of Internal Jugular Vein on Postoperative Complications in Abdominal Surgeries: A Prospective Randomized Controlled Trial

NCT: NCT07041021 · Status: RECRUITING · Phase: N/A · Sponsor: Suez Canal University · Started: 2025-07-15 · Est. Completion: 2026-05

Official Summary

This study investigates the role of respiratory variation in the internal jugular vein as a tool for intraoperative fluid management during abdominal surgeries under general anesthesia. The purpose of this clinical trial is to reduce postoperative complications and improve patient outcomes through proper intraoperative fluid management. The main question it aims to answer is: Can intraoperative fluid management guided by the respiratory variation of the internal jugular vein during abdominal surgeries reduce postoperative complications? Research Hypothesis (Alternative Hypothesis): We hypothesize that fluid management guided by the respiratory variation of the internal jugular vein during abdominal surgeries can reduce postoperative complications. The patients will be divided into two groups and randomized to receive either intraoperative fluid therapy guided by the respiratory variation of the internal jugular vein or standard fluid therapy. Postoperative complications, length of hospital stay, total amount of fluid administered intraoperatively, use of vasopressors in both groups, and incidence of hypotensive episodes will be recorded.

Study Design

Study Type: INTERVENTIONAL
Allocation: RANDOMIZED
Model: PARALLEL
Masking: DOUBLE
Enrollment: 84 participants

Interventions

DIAGNOSTIC_TEST: Respiratory variation of the Internal Jugular Vein (IJV) — In the study group, the fluid therapy will be guided by the respiratory variation (RV) of the Internal Jugular Vein (IJV) throughout surgery. Fluid maintenance will be continued as long as the IJV diameter is less than 2 cm and the IJV RV is more than 18. If the IJV diameter exceeds 2 cm and the IJV RV is less than 18, fluids will be stopped.

Primary Outcomes

The primary outcome is the incidence of postoperative complications in both groups, which will be measured by the occurrence of any of the postoperative complications during the first seven postoperative days in both groups (The first seven postoperative days)

Secondary Outcomes

The length of hospital stay in both groups (Up to 30 days postoperatively.)
Assessment of the total amount of fluid administered intraoperatively in both groups (Intraoperatively (From the start to the end of the surgery))
Intraoperative vasopressor use in both groups (Intraoperatively (From the start to the end of the surgery))
Intraoperative hypotensive episodes in both groups (Intraoperatively (From the start to the end of the surgery))

Trial Locations

Suez Canal University Hospitals, Ismailia, Ismailia Governorate, Egypt
Suez Canal University Hospitals, Ismailia, Egypt