A New Approach to Nutritional Therapy in Rheumatoid Arthritis: Evaluation of the Effect of the DASH Diet Through a Randomized Controlled Clinical Trial

Official Summary

In this study, it is aimed to determine the effect of the DASH diet model on the treatment of patients with seropositive rheumatoid arthritis, by evaluating its potential impact on inflammatory markers, disease activity scores, patients' functional status in daily life, and quality of life. "This study is being conducted as part of a doctoral dissertation, and due to insufficient initial awareness regarding the requirement for prior registration, the registration process was completed after data collection had already begun. However, data collection is still ongoing, and the study has not yet been completed. We remain committed to full compliance with clinical trial reporting standards and transparency."

Study Design

• Study Type: INTERVENTIONAL
• Allocation: RANDOMIZED
• Model: PARALLEL
• Masking: NONE
• Enrollment: 49 participants

Interventions

• OTHER: Dietary Approach to Stop Hypertension (DASH) Diet — "Dietary intervention: DASH diet" Participants in the intervention group will follow the Dietary Approaches to Stop Hypertension (DASH) diet for 12 weeks. The diet plan will be personalized based on each participant's 24-hour physical activity level and basal metabolic rate. Dietary adherence will be monitored through 3-day dietary intake records and DASH diet scores calculated using the Nutrition Information System (BeBiS). The intervention aims to assess the effect of the DASH diet on inflamma

Primary Outcomes

• Change in Disease Activity Score-28 (DAS-28) (Baseline, Week 4, Week 8, and Week 12)

Secondary Outcomes

• Change in Pain Score Measured by Visual Analog Scale (VAS) (Baseline, Week 4, Week 8, and Week 12)
• Change in Biochemical Parameters (Baseline, Week 4, Week 8, and Week 12)
• Change in Scores from Health Assessment Questionnaire (Baseline, Week 4, Week 8, and Week 12)
• Change in Scores from the Short Form-36 (SF-36) Health Survey (Baseline, Week 4, Week 8, and Week 12)

Trial Locations

• Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey (Türkiye)
• Istanbul Prof. Dr. Cemil Taşcıoğlu City Hospital, Istanbul, Turkey (Türkiye)

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