The Effect of Transcranial Magnetic Stimulation on Spasticity and Balance in Patients Diagnosed With Multiple Sclerosis
Official Summary
Recently, non-invasive brain stimulation modalities such as transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation have become treatment options. Among these methods, rTMS is a non-invasive brain stimulation technique that can affect descending corticospinal pathways, thereby modulating cortical excitability in the motor area where it is applied. This study will examine the effect of rTMS application on spasticity and balance in patients with multiple sclerosis. In addition, the indirect effects of the applications on gait pattern, joint range of motion, and pain will be evaluated.
Study Design
- Study Type: INTERVENTIONAL
- Allocation: RANDOMIZED
- Model: PARALLEL
- Masking: SINGLE
- Enrollment: 24 participants
Interventions
- DEVICE: rTMS — Low frequency rTMS application on M1 cortex
- DEVICE: sham rTMS — Low frequency sham rTMS
Primary Outcomes
- Modified Ashworth Scale (patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month)
- Penn Spasm Frequency Scale (patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month)
- Modified Tardieu Scale (patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month)
- BERG Balance Scale (patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month)
- Goal Attainment Scale (patients will be checked on first day of hospitalization and after treatment 1 month)
Secondary Outcomes
- Visual Analogue Scale (VAS) (patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month)
- Expanded Disability Status Scale (EDSS) (patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month)
- Functional Independence Measure (FIM) (patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month)
- Multiple Sclerosis Quality of Life-54 (MSQoL-54) (patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month)
- Six Minute Walk Test (patients will be checked on first day of hospitalization, after treatment at 2 weeks and after treatment 1 month)
Trial Locations
- Ankara Etlik City Hospital, Ankara, Yenimahalle, Turkey (Türkiye)
More Multiple Sclerosis Trials
AI-generated analysis for educational purposes only. This is not medical advice. Discuss clinical trial participation with your doctor. Data sourced from ClinicalTrials.gov.