Classification of Upper and Lower Limb Spasticity Patterns and Their Impact on Quality of Life in Patients With Multiple Sclerosis

Official Summary

Multiple sclerosis (MS) is a chronic neurological disease frequently associated with spasticity, which may lead to functional limitations and reduced quality of life. Although spasticity is common in MS, detailed descriptions of upper and lower extremity spasticity patterns are limited. A better understanding of spasticity patterns may help improve individualized rehabilitation and treatment planning. The aim of this study is to classify upper and lower extremity spasticity patterns in patients with multiple sclerosis and to investigate their association with quality of life. Adult patients with MS and clinical spasticity will be recruited from a tertiary care outpatient clinic. Spasticity will be evaluated using the Modified Ashworth Scale, and extremity postures will be recorded to define spasticity patterns. Functional performance will be assessed using the Timed 25-Foot Walk Test and the 9-Hole Peg Test. The impact of spasticity on quality of life will be evaluated using the Patient-Reported Impact of Spasticity Measure (PRISM). This prospective cross-sectional study is designed to provide a systematic description of spasticity patterns in patients with multiple sclerosis and to examine their relationship with functional outcomes and quality of life.

Study Design

• Study Type: OBSERVATIONAL
• Enrollment: 75 participants

Interventions

• OTHER: Observational Assessment — This is an observational study without therapeutic intervention. Participants will undergo clinical assessment of spasticity patterns, functional performance tests, and patient-reported outcome measures during a single study visit.

Primary Outcomes

• Classification of Upper and Lower Extremity Spasticity Patterns (Baseline (single study visit))

Secondary Outcomes

• Impact of Spasticity on Quality of Life (Baseline (single study visit))
• Lower Extremity Functional Performance (Baseline (single study visit))
• Upper Extremity Manual Dexterity (Baseline (single study visit))
• Spasticity Severity Assessed by the Modified Ashworth Scale (Baseline)

Trial Locations

• Marmara Üniversitesi Tıp Fakültesi, Istanbul, Maltepe 34854, Istanbul, Turkey (Türkiye)

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