Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort That is Associated With the Einstein Aging Study

Official Summary

The goal of this observational study is to learn how daily emotional stress affects cognitive function and inflammation in community-dwelling older adults aged 60 and older in Seoul, Republic of Korea. The main questions it aims to answer are: Does daily psychological stress measured in real-time affect short-term and long-term cognitive function in older adults? Do pro-inflammatory cytokines (such as CRP, IL-6, IL-10, and TNF-α) mediate the relationship between emotional stress and cognitive decline? How do social support and social isolation influence cognitive function and inflammatory biomarkers over time? Participants will: Complete baseline surveys assessing depression, cognitive function, and personal characteristics Use a smartphone app to answer brief surveys about their emotions, cognitive performance, and social interactions 1-6 times daily for two weeks Wear a Galaxy Watch to track sleep quality, heart rate, and physical activity Provide blood samples for inflammatory biomarker analysis Return for follow-up assessments at 6 months and 1 year This study is part of an international collaboration to establish a Korean cohort comparable to the U.S. Einstein Aging Study, with the aim of developing culturally tailored dementia prevention strategies.

Study Design

• Study Type: OBSERVATIONAL
• Enrollment: 180 participants

Primary Outcomes

• Incident MCI and Dementia Diagnosis (baseline, 6-month, 1-year, 5-year and 10-year follow-up)
• SNSB-2 Composite Score (Baseline and 12 months)
• Wechsler Memory Scale Score (Baseline, 6 months, and 12 months)
• Block Design Subtest Score (Baseline, 6 months, and 12 months)
• EMA Daily Cognitive Task Performance (Daily during 2-week EMA period at baseline, 6 months, and 12 months)

Secondary Outcomes

• EMA Daily Negative Affect (Daily during 2-week EMA period at baseline, 6 months, and 12 months)
• EMA Daily Positive Affect (Daily during 2-week EMA period at baseline, 6 months, and 12 months)
• Depressive Symptoms (Baseline, 6 months, and 12 months)
• EMA Daily Social Interaction Frequency (Daily during 2-week EMA period at baseline, 6 months, and 12 months)
• Daily Sleep Quality (Continuous during 2-week EMA period at baseline, 6 months, and 12 months)

Trial Locations

• Korea University, Seoul, Select One..., South Korea

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