Skeletal Muscle Aging and Responsiveness in Aged People With MS

Official Summary

The purposes of this study are to: 1) compare baseline muscle and cardiovascular health in older individuals (\>60 years old) diagnosed with MS to age-matched people without MS, 2) determine muscle and whole body changes to an exercise training program, 3) determine if the muscle in a more affected leg in individuals diagnosed with MS is different from the muscle of a less affected leg, and 4) if or how individuals diagnosed with MS adapt differently than age-matched people without MS to exercise training. Participation in this study will average 1.5 hours per visit, 3 visits per week, for approximately 4 months.

Study Design

• Study Type: INTERVENTIONAL
• Allocation: NA
• Model: SINGLE_GROUP
• Masking: NONE
• Enrollment: 10 participants

Interventions

• OTHER: Exercise trial consisting of both cardiovascular and strength training — All participants will receive 12 weeks of combined ET and RT. All exercise is supervised with a certified trainer. All study staff are CPR trained. Progression of volume and intensity will occur during the ramp-up week and into the first week of training. The ramp-up period increases the number of sets, repetitions, and intensity to limit excessive muscle damage, soreness, and fatigue. Full volume training will be achieved by the end of week one and progression thereafter will be based on intens

Primary Outcomes

• fMQ (Week -3 and Week -2)
• CRF (Enrollment to end of study at 18 weeks)

Secondary Outcomes

• Total and Regional Body Composition (Week -3 and Week -2)
• Muscle Biopsy (Week 1 and Week 12 Muscle Biopsy)
• Skeletal Muscle Phenotyping (Week 0, 6, and 12)
• Systemic Inflammation (Week 1 and Week 12)
• Muscle Inflammation (Week 1 and Week 12)

Trial Locations

• Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States

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